- Nidalee is the first champion that has access to 7 different active abilities, the second is Lee Sin.
- Nidalee, along with Kayle , Jayce, and Elise are the only champions to be both ranged and melee.
- Nidalee is one of a few champions to have multiple textures in one skin. One for her human form, and another for her cougar form to match.
- Nidalee is the first champion to feature a transformation ability. The others being Swain, Shyvana, Zyra and Elise.
- Nidalee was designed by Brackhar.
- Nidalee's voice actor's name is Kelly Fosdahl Burge
- Nidalee and Kayle are the only champions with ranged auto-attacks to have a base magic resistance per level.
- Nidalee has 4 running animations: her default human form run, her default cougar form run, her human form-bush sprint, and lastly her cougar form-bush sprint.
- Before her release Nidalee was rumored to have a special stackable DOT that could be applied by all her damaging abilities and her passive provided 2 seconds of stealth when leaving brush in cougar form. It was removed prior to her release.
- Nidalee used to be the only champion to have any ability put on a static cooldown. Specifically, the capped spell is her cougar form's Pounce. This was removed in patch V22.214.171.124.
- Her hidden passive gives an allied champion which has lower level than her 5 exp per 5 sec. (range about 550)
- Nidalee is one of the few champions to have an extra set of /command animations. When in cougar form, she changes her /taunt, /laugh, and /dance animations (though there is no voice change).
- All of Nidalee's skins change the appearance of her cougar form, However, the other skills remain the same.
- Snow Bunny Nidalee was only available during the Snowdown Showdown of 2009.
- Pharaoh Nidalee is a reference to Cleopatra Cleopatra the Seventh.
- Bewitching Nidalee was only available during The Harrowing of 2011.
- Nidalee has been dating the summoner and journalist, Bob Nashahago. However, through Blitzcrank's fleshling dating service, Nashahago was matched with Janna. Whether or not this is a matter of infidelity on his part is unclear, though Nidalee is seen in her cougar form facing down both Nashahago and Janna in a picture presented in Blitzcrank's "Successful Matches".