- Don't hesitate to spam your spells since Deadly Cadence makes each additional cast cheaper. Noxious Blast does not require a target, so maintaining your 5 stacks is easy with a decent-sized mana pool.
- Cassiopeia is a great harasser in all stages of the game. All three of her basic abilities, especially Noxious Blast, can be used constantly in lane to zone, capable of dealing huge amounts of damage over time at a safe distance.
- Noxious Blast has a slight delay; lead your enemy when targeting with Noxious Blast to ensure the hit, or use it on them when they will have to stand still to last-hit.
- Using Noxious Blast in the brush does not reveal Cassiopeia, so when in the side lanes, use the brush to your advantage to harass with little to no retaliation from enemy minions.
- When chasing/fleeing, be sure to use your Noxious Blast on an enemy champion to speed yourself up, and Miasma to slow them down.
- Using Miasma in the middle of the lane when enemy minions are coming will slow them and deal some damage giving advantage to your minions, this tactic is best used in pushes as intentionally pushing your lane during the laning phase opens yourself up to ganks.
- Since Miasma grants vision over the area affected, it can be used to check brush.
- Noxious Blast can also be used to check brush, as it gives you a movement speed bonus (and a buff icon) if an enemy is hit. If you cast it in a brush, and notice the buff icon, you know that an enemy is there.
- Twin Fang becomes extremely powerful if the target is poisoned, allowing you to deal out large amounts of damage with its low conditional cooldown.
- It is very highly recommended to smart cast Twin Fang, as it will make it much easier to land the maximum amount of Twin Fang allowed by the duration of your poison effects.
- If the situation is favorable, try to cast Twin Fang while directly on top of your target, as Twin Fang's reduced cooldown begins when the poisoned target is hit and not on spellcast.
- Due to Twin Fang having the potential to be constantly refreshed, don't be afraid to target durable melee champions if necessary. Unlike many other mages that rely on burst damage, Cassiopeia and her Twin Fang can realistically cut through tough enemies with time, accuracy, and enough mana.
- Try to use Petrifying Gaze offensively, and usually against more than one target. That said, it can also be used when being ganked to escape enemies.
- It is, however, safest to use it when a teamfight has happened. The enemy will be less likely to manage to turn around with their attention split amongst five champions - and more likely to all be facing you since that is largely required to fight your team.
- Using Petrifying Gaze followed by Miasma, Noxious Blast and Twin Fang can turn most 1v1 fights and mid game turret dives in your favor.
- Petrifying Gaze also allows Cassiopeia to be a very strong anti-ganker. Simply casting it when your lane opponent and the enemy ganker are in range, then bursting down the weaker one with your combo can turn the 2v1 into a 1v1. This tactic is the only effective when your Petrifying Gaze stuns both targets.
- Buying Twin Fang on a poisoned enemy gives her much more chasing potential, but don't forget hit enemy with Noxious Blast from time-to-time to refresh the poison and the movement speed bonus for yourself. along with using
- Cassiopeia if enough enemies have a high amount of magic resistance, as the potential low-cooldown and damage on Twin Fang lets Cassiopeia be less stringent in choosing targets compared to other mages. works fine on
- Buy spell vamp items like to quickly restore health when hitting poisoned targets with Twin Fang.
- A Cassiopeia allowing her to spam her spells more often with the extra mana and some health for survivability. This can then build offensively into an early or a more defensive . is a perfect early game item for
- Even if she doesn't need the mana, getting a Cassiopeia's ability power.
and then upgrading it into an will greatly increase
- Starting the game with a Cassiopeia even more affordable. to build afterwards will make spamming with
- Avoid building cooldown reduction. Because Noxious Blast's damage tick is constant and can only be reapplied, and using Twin Fang on a poisoned enemy reduces the cooldown to 0.5 seconds (which cannot be further reduced by CDR), Cassiopeia does not gain the significant benefit from CDR as other mages do.
- Therefore, Cassiopeia. will be the major purchase for when you want more damage as
- If you can predict when Cassiopeia will use Petrifying Gaze such as at the beginning of a fight or at the end, you can avoid the 2 second stun.
- Cassiopeia is a very powerful harasser. Noxious Blast allows her to give her lane opponnent a hard time, but also be wary for Miasma, as it can set you up for ganks, make landing Noxious Blast or especially Twin Fang extremely easy, or zone you from minions very effectively. Buying is a good and cheap way to limit her harassment.
- Cassiopeia is extremely proficient at 1v1 fights, having the most sustained damage of all mages. Therefore it is not recommended to engage her alone. Since Cassiopeia has very high ability power scalings, she remains a constant threat to AD carries late game, since if she lands her ultimate, she can easily kill an AD carry without resistances within the 2 second stun Petrifying Gaze provides her.
- Due to Noxious Blast and Miasma, Cassiopeia is very powerful at kiting. If she gets she will be almost impossible to reach if played correctly; do not engage her with a champion without strong gap closers while also being able to withstand her damage in a 1v1 fight.
- Avoiding her Noxious Blast and Miasma is critical for your survival, as they deal heavy DoT, and being poisoned allows Cassiopeia to spam her Twin Fang on you.