- Galio was designed by rjcombo.
- Galio is voiced by David Lodge, Who also voices .
- His /dance is the same as Belle and the Beast performed in the Beauty and the Beast from Walt Disney. Galio imitates the dance of the male lead.
- Enchanted Galio is a possible reference to Chernabog from the Disney film Fantasia.
- Hextech Galio has some resemblance to The Iron Giant from the eponymous Warner Bros movie, and some resemblance to the characters from the movie "9".
- Hextech Galio could be a reference to Clank from the Ratchet and Clank series.
- Commando Galio is a reference to the Imperial Guard of the Warhammer 40,000 series.
- Galio's Gatekeeper skin is one of the legendary skins at 1820RP which was released on April 23, 2012.
- His skin resembles Hellboy, a hero from Dark Horse Comics, due to his red skin, giant fists, demon horns, and chonmage hairstyle. His wings are the only contradiction to the likeness of Hellboy.
- The runes that mark the arms, also mark the cards of Underworld Twisted Fate. Showing a link between the two skins, as Galio guards the gate to the underworld.
- In early 2012, Galio's classic artwork, as well as those of , , and had their artwork replaced with the Chinese Classic artworks. Galio's classic artwork was changed again since then, however.
- Galio's Gatekeeper skin is the 3rd non-comical legendary skin. the 1st belonging to and the 2nd to
|Gatekeeper Galio's Theme|