While the Fortune synergy is active, losing a round increments a hidden counter by 1, that can go up to 9. This counter remains at the same value even if you disable the Fortune synergy. Winning a round gives you a reward based on the counter's number (high number, bigger reward) and resets the counter. Spatulas can drop from 5 Loss on.
The 3 Fortune synergy grants an approximate gold value of:
The 6 Fortune synergy gives the same effect as the 3 Fortune synergy, but winning a round gives an additional orb with a different loot table (worth an average of 11.65). This can drop a Spatula, and has a low chance to trigger a "Jackpot" (lots of items). The additional orb's value does NOT increase on losing rounds.