Active ability items are items that have an effect that may be activated by clicking on its icon or by pressing its assigned hotkey. Items can be clicked and dragged to different squares on the HUD in-game, allowing for greater control over hotkey usage.
- See also: consumable items.
Notes
- Selling an item with a unique active on cooldown, then rebuying it, will not reset the cooldown to its full duration, nor will it replenish the active. Its cooldown is constantly tracked in the background, ticking down even while the item isn't in the inventory. For instance, after selling
Blade of the Ruined King while it has 50 seconds left on its active cooldown, waiting 30 seconds, then purchasing it again, it will still have 20 seconds remaining. However, upgrading from 
Quicksilver Sash to 
Mercurial Scimitar is an exception to this rule as the cooldown is reset. - Using an item ability will interrupt channelled abilities such as
Katarina's Death Lotus.
Item actives
Affect yourself only
- Gargoyle Stoneplate
- Mercurial Scimitar
- Quicksilver Sash
- Seraph's Embrace
- Stopwatch
- Wooglet's Witchcap
- Youmuu's Ghostblade
- Zhonya's Hourglass
Affect allies only
Affect either yourself or an ally
Affect both yourself and allies
- Knight's Vow
- Locket of the Iron Solari
- Shurelya's Reverie
- Timeworn Face of the Mountain
- Timeworn Talisman of Ascension
- Zeke's Convergence
Affect enemies only
- Bilgewater Cutlass
- Hextech GLP-800
- Hextech Gunblade
- Ohmwrecker
- Randuin's Omen
- Ravenous Hydra
- Tiamat
- Timeworn Frost Queen's Claim
- Twin Shadows
