Talk:Wit's End/@comment-62.80.253.78-20110127094529/@comment-3067750-20110127122924

No... when the enemy can regenerate more mana than you can drain, this item loses its significance.

Wit's End is best purchased very early in the game (1st item) before enemy players can build up any kind of Mana Regeneration items (ie: Heimerdinger or Ryze) or against players with small mana pools who don't use Mana Regeneration items (ie: Malphite or Ashe)