User blog comment:Parrrley/Rune Setup for S4/@comment-12443575-20140524073000

Runes and masteries are mainly about the player's playstyle, there are no obligations or restrictions, but if you have no idea what would be good for you, you may want to use one of the "generic" setups: - Matched up against a physical-damage opponent or jungling: MR\level blues instead of flat MR - Mage\support mage\hybrid champ: hybrid pen reds\quints instead of magic pen for better AA harass - Matched up against a magic-damage opponent (and jungler!): HP or HP\level yellows instead of armor As for tanks, armor penetration\hybrid penetration\ASPD reds are better for clear speed, you may also find MS quints very useful for clear speed, but I personally prefer flat AP quints for better clear speed and better early ganks when playing Fiddle\Sejuani\Nunu