User blog comment:StrategicMagic/Vayne - Carry? Yes. AD? No./@comment-128.230.95.223-20120819213755/@comment-5052127-20120824004241

yeah, stacking health does normally counter true damage, but not vayne's because it does a % of your health, so you get no benefit from health at all vs her true damage... luckily most of her damage is physical, so some armor & health still helps against that.

You actually CAN mitigate some of her true damage by getting Frozen Heart, since it is slowing her attacks so she gets less silver bolts off (it really hurts all her other damage too)... FH counters her more than anything else.