Talk:Karthus/@comment-5259099-20130425090208/@comment-973379-20130503112727

Runes - AP or spellwamp quints quints, armor gold, armor or m.pen red, m.res/lvl or mana regen or ap/lvl blue. Masteries 21/9/0 - 21 in offence synergies very good with ult. Start with either cloth and 5 pots or machete and 5 pots(if you pplan to build SotSV). Then build tear and revolver asap, then catalist->roa. Then.. whathever you like(rabadon, abissal, rylai, WotA.. etc).

Q-E-Q-W-E-R then max R>Q>E>W. Important thing there - toggle E off before killing small monsters for mana sustain.

Ganks are good if you master Q and W, also you can towerdive like a boss if this will give you  team double - but be sure that you will take at least one kill when you suicide