User blog comment:Emptylord/Blogs/Where's the lore going?/@comment-1330314-20130805211935

LoL's lore revolves around gameplay updates, so it's unlikely that old rivals will get new interactions (though that would be amazing, and a lot more immersive). I'd really like to see the development on the whole Noxus situation, though unfortunately that may not happen. LoL doesn't really have a real plot to speak of, so it's unlikely that there'll be any development on current champions' stories (unless they remake them, in the same vein as the Freljord/Shadow Isles updates).
 * Noxus/Demacia: The rise of Swain got cut when the JoJ died. I'd really like to see what develops in Noxus. However, I'd be far more interested in digging up dirt on Demacia. We know it's a militaristic, totalitarian government that brainwashes its citizens, but so far there hasn't been a really nasty Demacian champion (not even Shyvana's that bad).
 * Nasus/Renekton: I think Renekton's too far gone for him to reunite with Nasus. Caitlyn and Vi are crimefighting partners, Nasus and Renekton want to kill each other. Renekton's a bloodyhirsty killer who hates his brother with a passion, and Nasus made it his mission to end Renekton before he could do any more harm.
 * Leona/Diana: There are actually a great deal many reasons Leona and Diana would never befriend each other. Leona may have been nearly executed by her people, but she immediately became their favorite when the Sun protected her. Diana's the complete opposite: she too was nearly executed, but even when the Moon favored her she was still an outcast. She hates the Sun and the Solari religiously (and literally so), and Leona, as the paragon of the Sun, sees her as a heretic. In a literary setting, they could bond over their isolation as children, but in LoL the only setting in which they meet is one where they fight.
 * Twisted Fate/Graves: Twisted Fate may not have anything against Graves, but Graves has every reason to kill TF. He tortured people just to find his whereabouts, and it's more or less a point of honor for him.
 * Kayle/Morgana: I don't think they actually want to "save" each other: Kayle disowned Morgana, who built up her power just to stand up against her sister, and joined the League just to defeat her. As with Leona and Diana, it's an ideological difference, which drives people apart the strongest.

I guess I'm not as optimistic as you in terms of relatioship building, but I fully second the notion of having more lore-related interactions between champions. I also wonder how Katarina and Cassiopeia get along: if it wasn't for the lore, I wouldn't have guessed they were sisters. There's also the whole Tryndamere/Ashe pairing which never got developed on.