User blog comment:Demise101/So I was thinking..../@comment-3360527-20110801012341

Honestly, the only ones I can forsee giving what you're looking for (OMGWTFRAPE) early game are:
 * Crit chance/crit damage (with lucky crits)
 * AP/Magic Pen (10 MPen from reds/1 quint, rest AP)
 * AD/ArP

They would have to be paired with the proper champion that can fully utilize the early game burst and/or have good CC to keep them from running.