Talk:Rune/@comment-71.61.122.70-20120411213204/@comment-108.74.28.222-20120427192815

runes and masteries exist to give an edge in the early game, when you have virtually no items. mid and late game they just become icing on the top. you can also use them to obtain moderate amounts of novelty stats, like tenacity, life steal or spell vamp, and CDR, while your items can focus on the more important AD, AP, AS, health, mana, and armor.