Talk:Kindred/@comment-5319740-20161017044124/@comment-28158401-20161023012008

Quotes from the wiki:

"Unique – Shock: Single target abilities and basic attacks on Champions (on-hit) consume 3% of current mana to deal 6% of current mana as physical damage. This effect only activates while you have greater than 20% maximum Mana ."

"Each Wolf attack applies spell effects as an area of effect ability."

So Muramana procs ONLY on single target abilities and Black Cleaver nor Rylai has such restrictions. Wolf's Frenzy is reated as an area of effect ability, so it does not proc Muramana passive, but that does not prevent it from applying Rylais slow nor armor debuff of Black Cleaver.

Black cleaver only cares of the damage type an attack or ability deals and Rylai only cares whether the ability is treated as a spell or not. Abilties that are on-hit effects or specifically stated that they apply on-hit effects (effectively treated as autoattacks - Ezreal and Gangplank Q for example) do not interact with Rylai's passive.

This practically all you need to know of these interations. Whether an ability is counted as an area of effect or not is quite arbitrary, but they usually have balance reasons behind the logic. Like Lucian would be totally broken if his ult was considered single target (it can effectively hit only one target although each shot can hit different target) and Muramana would thus proc on each shot. Now that with Black Cleaver would be totally bonkers.