User blog comment:TheTobarMethod/Guide To ADC/@comment-3541335-20130223193417/@comment-4709478-20130225033749

I agree with Andrew on this one.

However, killing the closest isn't always the best idea. Targeting the nearest, most dangerous target is more optimal, as long as you don't have anyone to peel the bastard off you.

About that anon, he's slightly right. However, in a teamfight scenario, the APC will normally blow quite a bit of their skillset, making them easy targets. If it's a chase scenario, either you'll only want to chase the APC if the APC is low on mana and health or there's 2 or more people chasing (this more depends on what APC you're chasing).