Talk:Rune/@comment-71.61.122.70-20120411213204/@comment-4923836-20120719104755

Runes are for early game stat increases (or late if you choose scaling) and lower end masteries are for early game, whereas the higher located ones are more for late, e.g. 6 armor / mr help early, but getting the 5% ap increase (mini deathcap) is more handy late.