Talk:Karthus/@comment-1920011-20140522215301

I don't know how well this will work for others, but I found spellvamp quints to be deceptively strong. Combined with the mastery, you can start the game with 9% spellvamp, which is fully applied on single-target Q's. Karthus has plenty of mana sustain in lane from his itemization. Converting some of that mana into health ensures that you can have a safe laning phase and simply powerfarm your way to late-game.