Talk:Ezreal/@comment-3543846-20110530144007/@comment-4031457-20110531124140

It's hard to go wrong with Ezreal's masteries IMO, though pure AP Ez has more obvious routes. 21/9/0, 21/0/9, 9/0/21, 9/21/0, and then even stranger things like 23/6/1, 15/0/15, 12/0/18, 11/0/19 - any of these could work on an AD/Hybrid. If you're rushing a Tear/Manamune, you'll definitely want the Strength of Spirit mastery for the awesome hp/5. If not, any of those.

The reason I don't spec any Defence is because I find that Ez has the supreme ability to stay out of danger, especially once you build Banshee's and have some CDR. Seriously, spec what you want based on what works for you, though you'll probably want at least 12 in Offence for the armour pen and %magic pen.