Talk:Vladimir/@comment-7878249-20130419183135/@comment-4538269-20130419215458

Well E has a slight delay whereas Q hits instantly. Like I mean if you're in range to cast Q and you cast it, it will hit. But with E, there is a slight delay before the spell actually activates and during that activation time, the enemy could've already moved away meaning you just lost HP for no reason.

Although maybe I'm not understanding what you're trying to ask here but honestly the order isn't too important. Do keep in mind however that the Empowered buff does affect the inherent healing component of Transfusion so getting the buff or extra stack first would be beneficial.