Talk:Karthus/@comment-166.248.72.0-20120528034454/@comment-198.96.33.38-20120528045547

It really depends on you. To be truly effective, Karthus needs at least one health item. That's going to be either RoA or Rylai's. Getting both RoA and Archangel's is cost-ineffective unless you have a good early game. So, choose between RoA, or Archangel's and Rylai's. I prefer the second one myself, but try both and get back to us.

TL;DR - Either something like Boots > Catalyst > RoA or something like Tear > Boots > Giant's Belt