User blog comment:Fistful of Force/The one quality required to play assassin is to hate ADC./@comment-3275908-20120829094528

USUALLY this is correct. Assassins like Talon, Kassadin, Akali, Irelia... they should usually go for the carry, whether AD or AP, because those are the main damage dealers (typically it's the AD first, AP second).

You might be against some really nasty disruptors like Mundo, Alistar, or Malphite, but they're just distractions. Do your best to ignore them and kill the damage first, then the others should be a cakewalk to take care of.