Talk:Quintessence/@comment-187.147.33.123-20111130011203/@comment-4089515-20111201001702

as a general rule, the per level runes give more at 18 (obviously), but runes are the most useful at low levels, so flat ones are better in my opinion. You get more in regen later in the game, so the runes will be immaterial if they don't help you earlier.