Talk:Ryze/@comment-3543691-20110412102234/@comment-3325853-20110414143929

Best combo is QREQWQ...    R+E makes the second Q be cast before the first one even hits the target...E hits before the second Q so you have its MR reduction active for the 2nd and 3rd Q and also the W.      With smart casting you can drop QREQW on them essentially instantly and then the snare is long enough for the third Q.

Q is his real damage so that's what you want to get the most of....starting with W should only be for a fleeing target that will be out of range otherwise. If you have to start with W, then you do WQREQ....again letting R+E make the second Q nearly instantaneous. Maximizing the number of Q is his big damage.