Talk:Nasus/@comment-87.211.80.3-20111030104118/@comment-50.103.26.96-20111109201427

Blue CDR is great if you skill for CDR in masteries. The only other strong pick for Glyphs on Nasus are Magic Resist (like everyone else, natch). CDR reduces the early cooldown on Siphoning Strike significantly, and lets you get more last hits in earlier (with proper mana management, this is easily accomplished). 2.4second Siphoning Strike is brutal come mid-game, and you won't be getting that 40% CDR without Blue CDR runes (or Blue Buff, which almost ALWAYS needs to go to someone more important than Nasus).

Mana Regen Seals are very strong on Nasus, but so is early armor (or Dodge, if you ignore Merc's Treads for Tabi). Get MS Quints to help against early game kiting, otherwise, Armor Pen, Flat CDR or AD Quints all work fine.