Talk:Nautilus/@comment-24198515-20150108125935/@comment-5266525-20150115084728

Attack speed runes are the best reds for clearing because an on-hit effect is your primary clearing skill. Recall that you always do half your damage on-hit and the rest over 2 seconds.

None of the basic monsters have any MR and you deal mostly magic damage anyway so you'd just be wasting slots by going hybrid penetration.