User blog comment:BerryBandit/Mechanically demanding champions/Quick decision champions/@comment-3974211-20130623125652

I don't think Twitch is at all. He requires to think more about positioning than many other carries, but he is not harder to use or requires any quicker reactions (the fact you put yourself into trickier positions with Ambush doesn't mean he innately requires better requires better reactions, you're just not playing him with the same level of caution you play other champions).

And Kayle's ability ranges are absurdly long for it to matter if she has good reaction time. Also, Kayles who rely on "good reaction time" are not normally the better Kayles. You shouldn't need good reaction time unless you're holding off on your ultimate until someone is dead, and Kayle's ultimate is more useful if you negate the first half of a fight.

My list would be

1) Syndra (her mechanics are more complicated and she isn't rewarded for it, which is why many players think she's underpowered) 2) Orianna (the reason Syndra isn't rewarded for being difficult to play, on-release Orianna had such a reward and was broken) 3) Thresh (his unique casting styles/delays and co-operative interaction makes him stick out when coming to from other champions) 4) Karthus/Cassiopeia (micromanagement on these champions is high, and if you can manage it they basically have on-release Orianna power) 5) Shaco (for Shaco to not be that shit-tier champion people resent for having on their team, the player needs to have mastered their mechanics and have amazing positioning.