User blog comment:Deshiba/Pre-Season Theor Craft: Twitch/@comment-1330314-20131219172004

While I think does proc all three stacks if used with  (assuming of course you hit three champions at once), I still don't think the masteries or the item would work well on  (in fact, he may be the worst-suited of marksmen for this): Twitch has only one spell that deals actual damage, as his passive counts as an on-hit effect, and the latter deals true damage, meaning it is completely immune to any form of damage increase. 3% extra damage on one spell isn't too good, and while he can also get all three stacks of with one cast of his E, you're going to be using the latter as an execute anyway (or at least once your enemies have six stacks of ), so the bonus damage is not going to be put to full use.

The other problem with this build is that Runaan's in general is not actually a good item for maximizing damage output on marksmen: for 400 more gold and 20% less attack speed, gives way better stats that will practically double your autoattack-based damage output (it increases it by 95% due to the crit and attack speed), whereas Runaan's only represents a 70% increase to your base DPS against your main target. The bolts are nice, but you're going to be focusing on one target at a time, so they're largely wasted. is also not a mastery I'd recommend on ranged champions, particularly marksmen, as it'll make you squishier, which is the last thing you need, and is nowhere near as effective as it is on melee champions.

Going duo top sounds better than going duo mid as well, even if you're planning to roam. In doing so you're either going to have to sacrifice the jungler position (which represent a significant cash flow advantage to your opponents) or leave only one player bot (which will allow their enemy marksman to farm a lot more safely and thus get fed faster), both of which leave mid lane in particular significantly more exposed to ganks from the other laners. Top would give you more leeway and more room to push (plus bigger odds of going against a melee champion), but any of these setups would leave your team at a gold disadvantage.

If you want to try something funky, try jungle Twitch. His clear times are not bad at all, and his ganks are amazing.