Talk:Ryze/@comment-6235836-20130208142947/@comment-128.153.217.185-20130208172842

Ability details is your friend here. Just replace " procs  spell vamp  and    Rylai's slow  similarly with all multi target spells and abilities with diminished effect" with "does not proc the bonus on-hit damage from Muramana".

In other words, Desperate Power's AoE damage will not benefit from Muramana. The target of the abilities you use in that time will take the bonus damage, but everyone around them will not. Afaik.

As for Spell Flux, it's technically single-targeted, but it does hit multiple targets. I'd think it wouldn't proc the Muramana bonus, but if you're still not sure, just try it out in a custom game.