Forum talk:Neekerivittu/@comment-11766967-20131002225651/@comment-4843863-20131014152127

Combo once you have most of your items should be:

R-E-Q-BoRK-Hydra (if you have it)-Ignite-E

Immediately after this your mark will detonate. If they are somehow still alive, just W to chase them for the kill, or let ignite do the work if they're low enough.