User blog comment:BerryBandit/Mechanically demanding champions/Quick decision champions/@comment-7007348-20130623054610

Between Elise and Vayne, I'd personally say Vayne. She is

1) ADC, while Elise is often built quite tanky in top or jungle 2) More difficult to manage in a teamfight due to Final Hour/ Tumble stealth mechanics, compared to Elise's Rappel.

But Elise has 7 abilities and that can play a big role. In terms of the entire League, I think the champ that requires the fastest reflexes is Lee Sin.

Do you even Insec?