User blog comment:Johannah14/Maxing some Abilities/@comment-8506165-20130530154809

I always max Q first on Vayne because having a positioning ability that enhances your next autoattack to boot is vital on an ADC as squishy as Vayne in my opinion. W isn't that helpful early game - it's only an extra 4% of health on every third attack compared to rank 1, which is huge lategame but early, you're not going to be attacking as frequently, their healthpools aren't as high, and you're not necessarily going to be able to attack an enemy champ three times in a row in lane, while it's much easier in a skirmish mid-late game.

My friend who also plays Vayne swears by W first, but I just think 40 extra true damage (at a point where no-one has that much armor anyway) and 4% extra max health damage (at a point where no-one has that much health anyway) doesn't really make sense compared to having a 300-range dash available every 2 seconds instead of every 6. Besides, go for it second and you start levelling it at exactly the same moment you get some lovely attack speed to synergise with it, rather than having it maxed when all you have is your vamp scepter and boots of speed.