User blog comment:ChaseKing/Counter for Leblanc finally found???/@comment-180677-20150605113734/@comment-3308937-20150605163742

Gotta agree with Dark here, Annie's W and R are technically skillshots but they're practically instant and cover a large-enough AoE that gameplay-wise they're almost as reliable as targeted spells and even then Annie does have a targeted skill (her Q) to use on her stun to guarantee she lands her R+W against LeBlanc.

I do think there are better champs though, like Malzahar and Anivia, who can use their waveclear to deny her potential roaming and can shut her down pretty handily if she tries to go in on them (dashing right into Anivia's Q or Malz's full combo) but Annie is definitely more reliable.