User blog comment:TheTobarMethod/Ryze The Pub Stomper/@comment-62.240.89.240-20130130203612/@comment-5263329-20130130204637

Let me think of a list of champions that can beat ryze mid (including semi-troll picks)...

Kassadin, talon, cassiopeia, yi, brand, cho'gath, fiddlesticks, kennen, leblanc, lux, malphite, maokai, morgana, soraka, TF, urgot, viktor, vlad, xerath, zed, ziggs, zyra.

tl;dr:

ryze gets raped by a lot of champions.