User blog comment:Demise101/So I was thinking..../@comment-98.248.174.227-20110729131034

I've got a Flat AD red+quints page. It's massive auto damage early on, though it seem to me my ArPen red/Quint page has almost the same damage on champs. Last hitting becomes a breeze though. Ashe-> flat ADs + 21/09 + doransblade does an obscene 225 burst (150 crit + 75ish volley) at level 1. Makes 4 bar mages piss their pants.

Used to run flat AD red/quints + flat AP blues for the old Kayle. Lvl 1 E -> 100 damage autos. Insane early.

mpen red/quints/blues. This page is WIN. 19 mpen will make your burst feel so bursty. On certain champs, it crushes (Leblanc). It also scales decently lategame. I use this whenever I don't need the small amount of survivability runes give or CDR.

CDR per level quints/blues. + one flat CDR yellow. 16.2% CDR at lvl 18. +9% from masteries, means you only need 15% to reach cap, which is easily done with boots of lucidity. Is awesome for champs that need max CDR, but you don't like the horrible CDR itemizations (Orianna, supports work well, although a lot of aura support items give CDR).

You should also consider mixed MPen and AP runes (because you need to balance the scaling stats for maximum damage). Although this is messed up by the fact that MPen gives increasing returns the closer you get to full penetration (I think).