User blog comment:Lokiwg/Runes Lets talk about them!/@comment-24795478-20140903105506

IMO about resistance: scale >flat  if you prefer to play safe or not under any harassment of enemy ( i use it for jungler and ryze, cause), flat> scale if you want to get early game advantage and withstand enemy early harassment with more ease ( if you are/against pantheon, graves or sthing like that). Or you can mix them for a stable early to late game with no real advantage