User blog comment:CCoville/So many Runes... so little IP/@comment-3213322-20110427151833

For the sake of efficient IP expenditure, I would advise you to focus on buying runes in the order of: armor seals, magic resist glyphs, armor pen marks, magic pen marks.

I would take a look at what tanks/offtanks you like to use before determining whether you would prefer to buy movement speed quints over health quints.

In most cases for a melee dps/fighter I would prefer armor penetration and armor over attack speed and dodge. Attack speed is easier to itemize for and doesn't help your early game as much. Dodge is less reliable of a defense.

I haven't played Irelia much, but most junglers benefit greatly from armor seals. I would at least put those in if you're having trouble.