User blog comment:Lokiwg/Runes Lets talk about them!/@comment-24705410-20140903204052/@comment-24795478-20140904041900

most general rune setup ( suit ad and bruiser ) is 9 ad red, 3 ad quint, armor seal and magic resist glyph, scale or flat in your decision ( it's suit, but not best build in some case, FYI)

AP most general rune setup : 9 MPen red, 3 AP quint, armor/health seal, magic/ap glyp (suit for mage and AP sp like sona, karma, etc, but you should get armor seal to lower physical harassment)

3rd page you should build hybrid pen ( the most expensive rune ) with armor and magic resist ( fit hybrid like akali, shyvana,jax, mundo, etc)

4th page you should build attack speed, armor and magic resist ( fit ADC with high base AD or kayle, or champs benefit from attack speed more than other stats, ie vayne )

And if you want to play some champs with specific rune setup, you must get more and build it your self, but these 4 rune page should cover most of situations.