User blog comment:Doctursea/Weakest of their league/@comment-60764-20121030010054/@comment-5441738-20121031004012

I'm not going to claim that Vayne is the best ADC, only that she's still viable without buffing. I think that she will perform a lot better on the new Twisted Treeline, as the Sanguine Blade also demands a higher attack speed in your kit, thus synergizing with her even better than more typical ADC items like Infinity Edge. Also, Van Damme's Pillager will help with how squishy she is considerably, adding spellvamp to her Silver Bolts and giving her some extra CDR and max health.