User blog comment:StrategicMagic/Vayne - Carry? Yes. AD? No./@comment-5266525-20120819110651/@comment-4434378-20120819134319

^ You can counter Vayne's true damage, sort of.

^^ Vayne doesn't really spec for armor penetration either. I can see On-hit Vayne working to an extent, the biggest problem with it is that you need Lifesteal, and the on-hits don't effect it.

I'm tempted to try Xin Zhao style build onf Vayne, emphasizing AS/Tankiness. Could be interesting.