Talk:Ryze/@comment-5282254-20150426190832/@comment-5663971-20150428121252

The tradeoff when compared to Seraphs is barely worth it. Seraphs increases damage via AP and AP gained though mana pool, Muramana increases it via Autoattack damage and toggle. Seraphs gives a shield though. and Muramana toggle works on Q but Q is a skillshot now, and depleting Ryze's mana pool faster is not good, he eats mana real fast already and has no way to recuperate except blue buff.

Taking both items might get you too squishy of a build.